Recent Advances in C–H Activation and Functionalization of Quinazolinones/ Quinazolines
N. Umadevi, G. Kumar, N. C. Gangi Reddy, B. V. Subba Reddy
Abstract
This review summarizes the transition metal-catalyzed direct C–H functionalization of quinazolinones and quinazolines through C-C, C-N and C-O bond formations. It focuses mainly on the C-H (sp<sup>2</sup> or sp<sup>3</sup>) bond arylation, amination, sulfamidation, acetoxylation, halogenation, annulation of quinazolinones and quinazolines. This review illustrates the scope of C-H activation and functionalization of various quinazolinone and quinazoline derivatives.
Topics & Concepts
ChemistrySurface modificationAminationAnnulationQuinazolinoneHalogenationCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisPhysical chemistryQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry