Taurine/Choline Chloride Deep Eutectic Solvent as a Novel Eco-Compatible Catalyst to Facilitate the Multi-Component Synthesis of Pyrano[2,3-<i>d</i>]Pyrimidinone (Thione), Hexahydroquinoline, and Biscoumarin Derivatives
Mohammad Biglari, Farhad Shirini, Nosrat O. Mahmoodi, Mehdi Zabihzadeh, Mohaddeseh Safarpoor Nikoo Langarudi, Meysam Alipour Khoshdel
Abstract
In this study, taurine/choline chloride deep eutectic solvent has been synthesized, characterized and used as an eco-compatible catalyst in the synthesis of pyrano[2,3-d]pyrimidinone (thione), hexahydroquinoline, and biscoumarin derivatives. The significant features of the present method are biodegradability, cost efficiency, easy preparation of the catalyst, short reaction times, production of target compounds in high yields, and simple work-up procedure. Also, the catalyst can be recovered easily and reused for several cycles in the studied reactions.
Topics & Concepts
Choline chlorideChemistryDeep eutectic solventCatalysisEutectic systemSolventChlorideTaurineComponent (thermodynamics)Organic chemistryCombinatorial chemistryBiochemistryThermodynamicsAlloyPhysicsAmino acidMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Biological Evaluation