Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies
Nehar Celikkin, Dario Presutti, Fabio Maiullari, Ersilia Fornetti, Tarun Agarwal, Alessia Paradiso, Marina Volpi, Wojciech Święszkowski, Claudia Bearzi, Andrea Barbetta, Yu Shrike Zhang, Cesare Gargioli, Roberto Rizzi, Marco Costantini
Abstract
In the last decades, biomedical research has significantly boomed in the academia and industrial sectors, and it is expected to continue to grow at a rapid pace in the future. An in-depth analysis of such growth is not trivial, given the intrinsic multidisciplinary nature of biomedical research. Nevertheless, technological advances are among the main factors which have enabled such progress. In this review, we discuss the contribution of two state-of-the-art technologies–namely biofabrication and organ-on-a-chip–in a selection of biomedical research areas. We start by providing an overview of these technologies and their capacities in fabricating advanced in vitro tissue/organ models. We then analyze their impact on addressing a range of current biomedical challenges. Ultimately, we speculate about their future developments by integrating these technologies with other cutting-edge research fields such as artificial intelligence and big data analysis.