Cytotoxic triterpenoids from Chisocheton pentandrus
Supriatno Salam, Desi Harneti, Rani Maharani, Nurlelasari Nurlelasari, Agus Safari, Ace Tatang Hidayat, Ronny Lesmana, Mohamad Azlan Nafiah, Unang Supratman, Thomas A. K. Prescott, Yoshihito Shiono
Abstract
Eleven undescribed triterpenoids (pentandrucines A to K) were isolated from the n-hexane extract of the stem bark of Chisocheton pentandrus (Blanco) Merr. These comprised ten undescribed dammarane-type triterpenoids and one undescribed apotirucallane-type triterpenoid. Additionally, two dammarane-type triterpenoids, four apotirucallane-type triterpenoids and two tirucallane-type triterpenoids were also isolated. The chemical structures of pentandrucine A-K, were fully elucidated using 1D and 2D-NMR, and high resolution MS. All of the compounds were evaluated for cytotoxic activity against MCF-7 breast cancer cells in vitro. Melianodiol proved to be the most active with an IC50 of 16.84 μM comparing favourably with Cisplatin (13.2 μM).