A Giese reaction for electron-rich alkenes
Qi Huang, Sankar Rao Suravarapu, Philippe Renaud
Abstract
Giese reaction not anymore limited to electron poor alkenes! A general method for the radical mediated hydroalkylation of electron rich alkenes including enol ethers, silylenolethers, enamides, and enecarbamates has been developed.
Topics & Concepts
EnolTriethylboraneReagentChemistryHydrogen atomStereoselectivitySilylationMedicinal chemistryPhotochemistryOrganic chemistryCombinatorial chemistryCatalysisAlkylChemical Synthesis and ReactionsSulfur-Based Synthesis TechniquesAsymmetric Synthesis and Catalysis