Nrf2-mediated liver protection by 18β-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3β pathway
Zhangting Wang, Jiang Ma, Yisheng He, Kai-Kei Miu, Sheng Yao, Chunping Tang, Yang Ye, Ge Lin
Topics & Concepts
Protein kinase BGSK-3PharmacologyOxidative stressPI3K/AKT/mTOR pathwayChemistryLiver injuryGSK3BAlkaloidKinaseBiochemistryToxicityPhosphorylationPhosphatidylinositolSignal transductionBiologyOrganic chemistryStereochemistryPlant Toxicity and Pharmacological PropertiesPlant-based Medicinal ResearchPharmacological Effects of Natural Compounds