Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease
Katharina Hopp, Emily K. Kleczko, Berenice Y. Gitomer, Michel Chonchol, Jost Klawitter, Jost Klawitter, Uwe Christians, Jelena Klawitter, Jelena Klawitter
Abstract
This report delineates the evolution of metabolic changes occurring during autosomal dominant polycystic kidney disease (ADPKD) progression. Using an orthologous model, we performed kidney metabolomics and confirmed dysregulation of metabolic pathways previously found altered in nonorthologous or rapidly-progressive PKD models. Importantly, we identified novel alterations, including augmentation of kynurenines, polyamines, and indoles, suggesting increased inflammation and microbial dysbiosis that provide insights into PKD pathomechanisms and may prove helpful for diagnosing, monitoring, and treating ADPKD.