Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection
Mariela P. Cabral-Piccin, Laura Papagno, Xavier Lahaye, Federico Perdomo-Celis, Stevenn Volant, Eoghann White, Valérie Monceaux, Sian Llewellyn‐Lacey, Rémi Fromentin, David A. Price, Nicolas Chomont, Nicolas Manel, Asier Sáez‐Cirión, Victor Appay
Abstract
BACKGROUND: T cell responses against HIV-1. METHODS: T cells were assessed using flow cytometry and molecular analyses of gene transcription. FINDINGS: T cells elicited in the presence of cGAMP were polyfunctional and highly sensitive to antigen stimulation, even after priming from people living with HIV-1. INTERPRETATION: T cell-mediated immunity against HIV-1. FUNDING: This work was funded by INSERM, the Institut Curie, and the University of Bordeaux (Senior IdEx Chair) and by grants from Sidaction (17-1-AAE-11097, 17-1-FJC-11199, VIH2016126002, 20-2-AEQ-12822-2, and 22-2-AEQ-13411), the Agence Nationale de la Recherche sur le SIDA (ECTZ36691, ECTZ25472, ECTZ71745, and ECTZ118797), and the Fondation pour la Recherche Médicale (EQ U202103012774). D.A.P. was supported by a Wellcome Trust Senior Investigator Award (100326/Z/12/Z).