Emergence and Genomic Characterization of Neisseria gonorrhoeae Isolates with High Levels of Ceftriaxone and Azithromycin Resistance in Guangdong, China, from 2016 to 2019
Xiaomian Lin, Wentao Chen, Yuqi Yu, Yinyuan Lan, Qinghui Xie, Yiwen Liao, Xing Wu, Sanmei Tang, Xiaolin Qin, Heping Zheng
Abstract
Here, we report five sporadic dual-resistant isolates, including FC428-related ceftriaxone-resistant clones with MICs of ≥0.5 mg/L and high-level azithromycin resistance with MICs of ≥1,024 mg/L. This study highlights that dual-resistant clones with the same evolutionary origin as FC428, A2735, and F89 have circulated in Guangdong, China, which suggests that the capacity for antibiotic resistance testing and genome analysis should be strengthened in daily epidemiological surveillance.
Topics & Concepts
Neisseria gonorrhoeaeAzithromycinCeftriaxoneMicrobiologyBiologyAntibiotic resistanceDrug resistanceNeisseriaGenotypingAntibioticsGeneticsGenotypeGeneBacteriaReproductive tract infections researchBacterial Infections and VaccinesSyphilis Diagnosis and Treatment