Design, synthesis, and molecular dynamics-driven evaluation of quinoline-sulfonamide derivatives as potent and selective EGFR inhibitors with promising anti-cancer efficacy and safety profiles
Mahmoud S. Elkotamy, Mohamed K. Elgohary, Islam A Elkelesh, Mahmoud Abdelrahman Alkabbani, Eman F. Khaleel, Wagdy M. Eldehna, Hatem A. Abdel‐Aziz
Topics & Concepts
ChemistrySulfonamideQuinolineCombinatorial chemistryEGFR inhibitorsCancerMolecular dynamicsPharmacologyComputational biologyEpidermal growth factor receptorBiochemistryStereochemistryComputational chemistryOrganic chemistryInternal medicineMedicineReceptorBiologyLung Cancer Treatments and MutationsCancer therapeutics and mechanismsEnzyme function and inhibition