Piezo channels modulate human lung fibroblast function
Mengning Zheng, Yang Yao, Niyati A. Borkar, Michael A. Thompson, Emily Zhang, Li Y. Drake, Xianwei Ye, Elizabeth R. Vogel, Christina M. Pabelick, Y. S. Prakash
2024American Journal of Physiology-Lung Cellular and Molecular Physiology23 citationsDOIOpen Access PDF
Abstract
The lung is an inherently mechanosensitive organ that can respond to mechanical forces in adaptive or maladaptive ways, including via remodeling resulting in increased fibrosis. We explored the mechanisms that link mechanical forces to remodeling using human lung fibroblasts. We found that mechanosensitive Piezo channels increase with stretch and mediate extracellular matrix formation and the fibroblast-to-myofibroblast transition that occurs with stretch. Our data highlight the importance of Piezo channels in lung mechanotransduction toward remodeling.
Topics & Concepts
Human lungFibroblastLung functionFunction (biology)Cell biologyNeuroscienceLungBiologyMedicineInternal medicineGeneticsCell cultureErythrocyte Function and PathophysiologyIon channel regulation and functionChemical and Physical Studies