Mammalian mitochondrial DNA replication and mechanisms of deletion formation
Maria Falkenberg, Claes M. Gustafsson
Abstract
Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome (mtDNA) that codes for subunits of the oxidative phosphorylation machinery. Mutations in mtDNA cause a number of rare, human disorders and are also associated with more common conditions, such as neurodegeneration and biological aging. In this review, we discuss our current understanding of mtDNA replication in mammalian cells and how this process is regulated. We also discuss how deletions can be formed during mtDNA replication.
Topics & Concepts
Mitochondrial DNABiologyGeneticsDNA replicationMitochondrionGenomeNeurodegenerationDNAOrigin of replicationOxidative phosphorylationDNA repairCell biologyGeneBiochemistryPathologyDiseaseMedicineMitochondrial Function and PathologyMetabolism and Genetic DisordersATP Synthase and ATPases Research