A solid-supported organocatalyst for asymmetric Mannich reaction to construct C2-quaternary indolin-3-ones
Jian‐Xiong An, Fen‐Fen Yang, Pan Wang, Zhicheng Gu, Yan Li, Lei Chen, Yong‐Long Zhao, Bin He
Abstract
-indol-3-ones and aldehydes/ketones. A series of C2-quaternary indolin-3-ones were prepared in good yields (up to 83%) and with excellent diastereoselectivities (up to 20 : 1) and enantioselectivities (up to 99% ee). In addition, the organocatalyst can be recovered by simple filtration and also be reused for the asymmetric Mannich reaction without significant loss of catalytic efficiency.
Topics & Concepts
ChemistryMannich reactionCatalysisFiltration (mathematics)OrganocatalysisOrganic chemistryChlorideArylCombinatorial chemistryEnantioselective synthesisAlkylMathematicsStatisticsAsymmetric Synthesis and CatalysisOxidative Organic Chemistry ReactionsChemical Synthesis and Reactions