Rational Design of Photochromic Analogues of Tricyclic Drugs
Fabio Riefolo, Rosalba Sortino, Carlo Matera, Enrique Claro, Beatrice Preda, Simone Vitiello, Sara Traserra, Marcel Jiménez, Pau Gorostiza
Abstract
subtype selectivity. These photoswitchable "crypto-azologs" of tricyclic drugs might open a general way to spatiotemporally target their therapeutic action while reducing their systemic toxicity and adverse effects.
Topics & Concepts
TricyclicPirenzepineChemistryPharmacologyIn vivoMuscarinic acetylcholine receptorAcetylcholineAntagonistReceptorStereochemistryBiochemistryMedicineBiologyBiotechnologyPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchSynthesis of Indole Derivatives