Colistin-phage combinations decrease antibiotic resistance in <i>Acinetobacter baumannii</i> via changes in envelope architecture
Xiaoqing Wang, Belinda Loh, Fernando Gordillo Altamirano, Yunsong Yu, Xiaoting Hua, Sebastián Leptihn
Abstract
infection model. Most importantly, we observed that phage-resistant bacteria that evolved in the absence of antibiotics exhibited an increased sensitivity to colistin, even though the antibiotic resistance mechanism per se remained unaltered. This increase in antibiotic sensitivity is a direct consequence of the phage-resistance mechanism, and could potentially be exploited in the clinical setting.
Topics & Concepts
Acinetobacter baumanniiPhage therapyMicrobiologyColistinAntibiotic resistanceBiologyAntibioticsBacteriophageGalleria mellonellaBacteriaVirologyVirulenceGeneEscherichia coliPseudomonas aeruginosaGeneticsBacteriophages and microbial interactionsAntibiotic Resistance in BacteriaMicrobial infections and disease research