Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer's disease
Yuanyuan Liu, Chu Han, Rongji Dai, Bo Li
Topics & Concepts
ChalconeChemistryNeuroprotectionBiochemistryTau proteinCytotoxicityProgrammed cell deathDocking (animal)Lead compoundStructure–activity relationshipAmyloid betaProtein aggregationSmall moleculeSenile plaquesCell biologyPharmacologyAlzheimer's diseaseIn vitroApoptosisStereochemistryPeptideBiologyDiseaseNursingPathologyMedicineDrug Transport and Resistance MechanismsCholesterol and Lipid MetabolismFerroptosis and cancer prognosis