A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome
Matthijs W. van Hoogdalem, Scott L. Wexelblatt, Henry T. Akinbi, Alexander A. Vinks, Tomoyuki Mizuno
Topics & Concepts
Physiologically based pharmacokinetic modellingOpioidMedicinePregnancyPharmacokineticsFetusGestationPharmacologyDrugInternal medicineBiologyReceptorGeneticsPrenatal Substance Exposure EffectsMaternal Mental Health During Pregnancy and PostpartumNeonatal Health and Biochemistry