Copper-catalysed <i>ortho</i>-selective C–H bond functionalization of phenols and naphthols with α-aryl-α-diazoesters
Ben Ma, Zhiqiong Tang, Junliang Zhang, Lu Liu
Abstract
Herein, we reported the first copper-catalyzed highly efficient C(sp2)-H functionalization of unprotected naphthols and phenols with α-aryl-α-diazoesters. In this transformation, CuCl2 efficiently promoted the highly chemo- and site-selective C-H bond functionalization under mild conditions, furnishing diverse phenol derivatives in moderate to excellent yields from readily available starting materials.
Topics & Concepts
Surface modificationChemistryPhenolsArylPhenolCopperCombinatorial chemistryOrganic chemistryMedicinal chemistryAlkylPhysical chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions