Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a
Paolo Casali, Tian Shen, Yijiang Xu, Zhifang Qiu, Daniel P. Chupp, John Im, Zhenming Xu, Hong Zan
Abstract
expression and CSR. Thus, our findings show that estrogen reverses the HDI-mediated downregulation of AID expression and CSR through selective modulation of miR-26a. They also provide mechanistic insights into the immunomodulatory activity of this hormone and a proof-of-principle for using combined ER inhibitor-HDI as a potential therapeutic approach.
Topics & Concepts
Downregulation and upregulationAutoantibodyImmunoglobulin class switchingPsychological repressionAntibodyEstrogenCancer researchChemistryMedicineImmunologyEndocrinologyGene expressionBiochemistryGeneB cellMicroRNA in disease regulationCytokine Signaling Pathways and InteractionsRNA Interference and Gene Delivery