Inflammatory Endotype-Associated Airway Resistome in Chronic Obstructive Pulmonary Disease
Xinzhu Yi, Yanjun Li, Haiyue Liu, Xiaomin Liu, Junhao Yang, Jingyuan Gao, Yuqiong Yang, Zhenyu Liang, Fengyan Wang, Dandan Chen, Lingwei Wang, Weijuan Shi, David Lam, Martin R. Stämpfli, Paul Jones, Rongchang Chen, Zhang Wang
Abstract
phenotypic testing, we showed that inflammatory endotype, the underlying pattern of airway inflammation, was most strongly associated with the airway resistome in COPD patients. There were distinct resistome profiles between neutrophil-predominant and eosinophil-predominant COPD that were associated with different bacterial species, host pathways, and inflammatory markers, highlighting the need of considering patient inflammatory status in COPD antibiotic management.
Topics & Concepts
EndotypeResistomePulmonary diseaseAirwayMedicineCOPDDiseaseImmunologyAntibioticsBiologyMicrobiologyInternal medicineAntibiotic resistanceIntegronSurgeryTracheal and airway disordersChronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseases