Size control of ropivacaine nano/micro-particles by soft-coating with peptide nanosheets for long-acting analgesia
Jing Liu, Weiwei Wu, Fei Peng, Deying Gong, Yi Lan Kang, Yujun Zhang, Congyan Liu, Yuncheng Li, Guoyan Zhao, Feng Qiu, Wensheng Zhang
Abstract
This study provided a facile strategy to prepare LA particles of different size and revealed the relationship between particle size, release rate and anesthetic duration, which provided both technical and theoretical supports for developing long-acting LA formulations with promising clinical application.
Topics & Concepts
RopivacaineCoatingNano-Materials sciencePeptideNanotechnologyBiomedical engineeringChemistryPharmacologyComposite materialMedicineBiochemistryAdvanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryNeuropeptides and Animal Physiology