Regulation and Evasion of Host Immune Response by African Swine Fever Virus
Lei Wu, Bincai Yang, Yuan Xu, Jinxuan Hong, Min Peng, Ji‐Long Chen, Zhongbao Song
Abstract
African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-stranded DNA virus belonging to the Asfarviridae family. Here, we review how the virus regulates the host immune response and its mechanisms at different levels, including interferon modulation, inflammation, apoptosis, antigen presentation, and cellular immunity.
Topics & Concepts
African swine fever virusVirusVirologyImmune systemBiologyClassical swine feverInterferonImmunityHost (biology)African swine feverImmunologyDNA virusInnate immune systemAcquired immune systemGeneGenomeGeneticsAnimal Disease Management and EpidemiologyVector-Borne Animal DiseasesViral gastroenteritis research and epidemiology