Electrochemical Decarboxylative Cyclization of α‐Amino‐Oxy Acids to Access Phenanthridine Derivatives
Yanling Zhan, Changhui Dai, Zitong Zhu, Ping Liu, Peipei Sun
Abstract
Phenanthridines are a class of useful heterocycles in the field of drug development. In this work, a method via electrochemical decarboxylative cyclization of α-amino-oxy acids to access phenanthridine derivatives was developed. This reaction proceeded through iminyl radical formation cascade intramolecular cyclization from readily available materials under environmentally friendly conditions. A wide range of phenanthridine derivatives were obtained in moderate to high yields.
Topics & Concepts
PhenanthridineChemistryElectrochemistryDecarboxylationIntramolecular forceCombinatorial chemistryOrganic chemistryCascadeCascade reactionEnvironmentally friendlyRadical cyclizationReaction conditionsIntramolecular reactionAromatizationRadicalReaction mechanismElectrophilic aromatic substitutionChemical synthesisRadical Photochemical ReactionsAdvanced Synthetic Organic ChemistryCatalytic C–H Functionalization Methods