Simple squaramide receptors for highly efficient anion binding in aqueous media and transmembrane transport
Giacomo Picci, Maciej Kubicki, Alessandra Garau, Vito Lippolis, Rita Mocci, Andrea Porcheddu, Roberto Quesada, Pier Carlo Ricci, Mariano Andrea Scorciapino, Claudia Caltagirone
Abstract
A family of acyclic squaramide receptors (L1-L5) have been synthesised with the aim to bind anions in a competitive solvent mixture and to evaluate how the presence of additional H-bond donor groups on the squaramide scaffold could affect the affinity towards anions and the transmembrane transport ability.
Topics & Concepts
SquaramideTransmembrane proteinChemistryAqueous solutionReceptorSolventIonCombinatorial chemistryBiophysicsBiochemistryOrganic chemistryBiologyOrganocatalysisCatalysisEnantioselective synthesisMolecular Sensors and Ion DetectionNeuroscience and Neuropharmacology ResearchLipid Membrane Structure and Behavior