Exercise-induced mitral regurgitation and right ventricle to pulmonary circulation uncoupling across the heart failure phenotypes
Francesco Bandera, Marta Barletta, Marianna Fontana, Sara Boveri, Greta Ghizzardi, Eleonora Alfonzetti, Federico Ambrogi, Marco Guazzi
Abstract
Ex-MR is a common mechanism across the spectrum of HF subtypes and combines with ventilatory inefficiency and RV-PC uncoupling. Interestingly, in HFpEF, Ex-MR emerged as unexpectedly prevalent and peculiarly associated with increased chronotropic response and peripheral O 2 extraction as potential adaptive mechanisms to backward flow redistribution.
Topics & Concepts
VentricleCardiologyInternal medicineMedicineHeart failureExercise intoleranceMitral regurgitationRight heart failurePulmonary hypertensionCardiovascular Function and Risk FactorsCardiovascular and exercise physiologyCardiovascular Effects of Exercise