Two new 2-arylbenzofurans from <i>Sesbania grandiflora</i> L. and their cytotoxicity towards cancer cell
Tjitjik Srie Tjahjandarie, Mulyadi Tanjung, Ratih Dewi Saputri, Devina Oktari Rahayu, Alfiah Nur Irza Gunawan, Muhammad Fajar Aldin
Abstract
Two new 2-arylbenzofurans, sesbagrandiflorain D (1) and E (2) along with two known 2-arylbenzofurans, spinosan A (3) and spinosan B (4) were isolated from the stem bark of Sesbania grandiflora L. The structure of two new compounds established by HRESIMS, 1 D NMR (1H, 13C) and 2 D NMR (HMQC, HMBC) spectra. Compounds (1-4) assayed for their cytotoxicity towards three human cancer cells (MCF-7, HeLa, and WiDr). Compound 1 showed very high activity against MCF-7 and WiDr with an IC50 value of 0.06 and 0.60 μg/mL, respectively.
Topics & Concepts
CytotoxicityHeLaStereochemistryIC50ChemistryCarbon-13 NMRCancer cellTraditional medicineTwo-dimensional nuclear magnetic resonance spectroscopyBark (sound)In vitroBiologyBiochemistryCancerMedicineEcologyGeneticsNatural product bioactivities and synthesisBioactive Compounds and Antitumor AgentsSesquiterpenes and Asteraceae Studies