Identification of Leptospiral Protein Antigens Recognized by WC1 <sup>+</sup> γδ T Cell Subsets as Target for Development of Recombinant Vaccines
Aline F. Teixeira, Alexandria Gillespie, Alehegne Yirsaw, Emily Britton, Janice C. Telfer, Ana L. T. O. Nascimento, Cynthia L. Baldwin
Abstract
Pathogenic Leptospira species cause leptospirosis, a neglected zoonotic disease recognized as a global public health problem. It is also the cause of the most common cattle infection that results in major economic losses due to reproductive problems. γδ T cells play a role in the protective immune response in livestock species against Leptospira , while human γδ T cells also respond to Leptospira .
Topics & Concepts
Recombinant DNABiologyVirologyAntigenIdentification (biology)Computational biologyImmunologyGeneticsGeneBotanyLeptospirosis research and findingsVeterinary medicine and infectious diseasesMycobacterium research and diagnosis