Construction of coacervate-in-coacervate multi-compartment protocells for spatial organization of enzymatic reactions
Yufeng Chen, Min Yuan, Yanwen Zhang, Songyang Liu, Xiaohai Yang, Kemin Wang, Jianbo Liu
Abstract
led to a distinct polymerization of dopamine. The spatial organization of different enzymes in immiscible coacervate phases, the distinct reaction fluxes between coacervate phases, and the enzymatic cascade network led to distinguishable signal generation and product outputs. The development of this multi-compartment structure could pave the way toward the spatial organization of multi-enzyme cascades and provide new ideas for the design of organelle-containing artificial cells.
Topics & Concepts
ProtocellCoacervateCompartment (ship)ChemistryEnzymeNanotechnologyBiochemistryMaterials scienceMembraneGeologyOceanographyLipid Membrane Structure and BehaviorRNA Research and SplicingProtein Structure and Dynamics