Bistable Photoswitch Allows in Vivo Control of Hematopoiesis
Lea Albert, Jatin Nagpal, Wieland Steinchen, Lei Zhang, Laura Werel, Nemanja Djoković, Dušan Ružić, Malte Hoffarth, Jing Xu, Johanna Kaspareit, Frank Abendroth, Antoine Royant, Gert Bange, Katarina Nikolić, Soojin Ryu, Yali Dou, Lars‐Oliver Essen, Olalla Vázquez
Abstract
causes MLL1 release with concomitant allosteric rearrangements in the WDR5/RbBP5 interface. Since our tool provides on-demand reversible control without genetic intervention or continuous irradiation, it will foster hematopathology and epigenetic investigations. Furthermore, our workflow will enable exquisite photocontrol over other targets inhibited by macrocycles.
Topics & Concepts
PhotoswitchIn vivoZebrafishBistabilityCell biologyEpigeneticsAllosteric regulationComputational biologyChemistryBiologyNanotechnologyNeuroscienceBiophysicsComputer scienceGeneticsBiochemistryMaterials scienceOptoelectronicsReceptorPhotochemistryGenePhotochromic and Fluorescence ChemistryZebrafish Biomedical Research ApplicationsPhotoreceptor and optogenetics research