NHC-Catalyzed Enantioselective [3 + 3] Annulation to Construct 5,6-Dihydropyrimidin-4-ones
Di Meng, Yangxi Xie, Qiupeng Peng, Jian Wang
Abstract
The unprecedented enantioselective NHC-catalyzed [3 + 3] annulation of α-bromoenals with amidines via a dual C-N bond formation is described. The protocol allows a rapid preparation of 5,6-dihydropyrimidinones in acceptable yields with good enantioselectivities.
Topics & Concepts
AnnulationEnantioselective synthesisChemistryCatalysisDual (grammatical number)Combinatorial chemistryOrganic chemistryStereochemistryMedicinal chemistryArtLiteratureN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis