In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants─Systematic Review and Meta-Analysis
Amrit Kaur Sandhu, Ying Yang, Wen‐Wu Li
Abstract
, the most tested bacterium in vivo. Covalent binding with polymer brush coating and physical layer-by-layer incorporation of AMPs were recognized as key methods of incorporation to achieve desired densities. The use of fusion peptides seemed admirable to incorporate additional benefits such as osteointegration and wound healing and possibly targeting more microbe strains. Further investigation into the incorporation methods, AMP activity against different bacterial strains, and the number of AMPs used for metal implant surface modification is needed to progress toward potential clinical application.
Topics & Concepts
In vivoAntimicrobialMeta-analysisAntimicrobial peptidesSurface modificationMaterials scienceMicrobiologyChemistryNanotechnologyBiomedical engineeringMedicineBiologyInternal medicineBiotechnologyPhysical chemistryAntimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsOrthopedic Infections and Treatments