An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis
Panpan Hou, Penghui Jia, Kongxiang Yang, Zibo Li, Tian Tian, Yuxin Lin, Weijie Zeng, Fan Xing, Yu Chen, Chunmei Li, Yingfang Liu, Deyin Guo
Abstract
Significance Regulation of inflammatory response is central to the outcome of microbial infection and inflammatory diseases. We demonstrated that ASB1, a member of the family of the ankyrin repeat and suppressor of cytokine signaling box (ASB) proteins, plays a previously unknown function in TAB2/TAK1-mediated inflammatory responses. ASB1 stabilizes TAB2 and consequently promotes the activation of downstream signaling pathways including NF-κB and MAPK pathways. The deficiency of ASB1 leads to less severe colitis and intestinal inflammation and protects mice from bacteria or lipopolysaccharide-induced septic shock. Such a finding has important implications in the understanding of inflammatory diseases and development of intervention measures related to ASB family proteins.