DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery
Jingyao Li, Daniel Ho, Martin Hénault, Chian Yang, Marilisa Neri, Robin Ge, Steffen Renner, Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler‐Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller, Jeremy L. Jenkins, Kathleen A. Worringer, Frederic Sigoillot, Robert J. Ihry
Abstract
-methyl-d-aspartate (NMDA) receptor, and independent off-target effects. Overall, the protocol and open-source analysis pipeline are a step toward industrializing RNA-seq for high-complexity transcriptomics studies performed at a saturating scale.
Topics & Concepts
Drug discoveryComputational biologyTranscriptomeDrugBiologyPipeline (software)Computer scienceBioinformaticsPharmacologyGeneGene expressionGeneticsProgramming languageSingle-cell and spatial transcriptomicsCRISPR and Genetic EngineeringRNA and protein synthesis mechanisms