Interfering in apoptosis and DNA repair of cancer cells to conquer cisplatin resistance by platinum(<scp>iv</scp>) prodrugs
Shuren Zhang, Xuanmeng Zhong, Hao Yuan, Yan Guo, Dongfan Song, Fen Qi, Zhenzhu Zhu, Xiaoyong Wang, Zijian Guo
Abstract
Platinum(<sc>iv</sc>) prodrugs targeting the DNA repair mechanism downregulate myeloid cell leukemia-1 (Mcl-1) and homologous recombination proteins (RAD51, BRCA2), thereby enhancing cytotoxicity against cisplatin-resistant cancer cells.
Topics & Concepts
CisplatinRAD51Myeloid leukemiaProdrugHomologous recombinationChemistryDNA repairCytotoxicityApoptosisCancer researchCancer cellDNAPlatinumDNA damageCell biologyMolecular biologyCancerBiologyBiochemistryChemotherapyGeneticsIn vitroCatalysisMetal complexes synthesis and propertiesDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniques