Delineation of the Direct Contribution of Candida auris <i>ERG11</i> Mutations to Clinical Triazole Resistance
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers
Abstract
to fluconazole resistance and the impact these mutations may have the susceptibility of the other triazoles remains unknown. The present study seeks to address this knowledge gap and potentially inform the future application the triazole antifungals for the treatment of infections caused by C. auris.
Topics & Concepts
FluconazoleCandida aurisVoriconazoleBiologyMicrobiologyTriazoleGeneticsAntifungalChemistryOrganic chemistryAntifungal resistance and susceptibilityFungal Infections and StudiesAntimicrobial Resistance in Staphylococcus