Manganese induces S-nitrosylation of PINK1 leading to nerve cell damage by repressing PINK1/Parkin-mediated mitophagy
Kuan Liu, Zhiqi Liu, Zhuofan Liu, Zhuo Ma, Yu Deng, Wei Liu, Bin Xu
Topics & Concepts
MitophagyParkinPINK1Cell biologyMitochondrionNeurotoxicityChemistryS-NitrosylationUbiquitin ligaseBiologyUbiquitinAutophagyBiochemistryApoptosisInternal medicineMedicineParkinson's diseaseToxicityCysteineEnzymeGeneDiseaseOrganic chemistryAutophagy in Disease and TherapyHeavy Metal Exposure and ToxicityParkinson's Disease Mechanisms and Treatments