Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities
Jianxin Han, Wei Liu, Miaomiao Li, Yanpei Gu, Ying Zhang, Tao Yuan
Abstract
In the current study, further chemical investigation of the fruiting bodies of Fomes officinalis led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I−O (1–7). Their structures were elucidated based on the analysis of spectroscopic data (HR-MS, 1D and 2D NMR, UV, IR). Compounds 1−3 possessed an unusual C-23 spirostructure moiety, while compounds 4−7 had 23,26-lactone unit. Anti-inflammatory assay revealed that compounds 3 and 5 exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells and cyclooxygenase (COX-2).
Topics & Concepts
LanostaneFomesTriterpenoidPolyporaceaeChemistryMoietyInonotus obliquusStereochemistryOfficinalisAnti-inflammatoryTriterpeneBiochemistryBotanyBiologyPharmacologyMedicinePathologyAlternative medicinePhytochemistry and Biological ActivitiesFungal Biology and ApplicationsNatural product bioactivities and synthesis