Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes
Shuya Du, Xiaojin Zhang, Yunxiao Jia, Peipei Peng, Qiuyue Kong, Surong Jiang, Yuehua Li, Chuanfu Li, Zhengnian Ding, Li Liu
Abstract
Taken together, these findings suggest that hepatocyte HSPA12A is a novel regulator that protects livers from LI/R injury by suppressing glycolysis-mediated HMGB1 lactylation and secretion from hepatocytes to inhibit macrophage chemotaxis and inflammatory activation. Therefore, targeting hepatocyte HSPA12A may have therapeutic potential in the management of LI/R injury in patients.
Topics & Concepts
HMGB1HepatocyteChemotaxisSecretionInflammationLiver injuryBiologyMacrophageMolecular biologyChemistryCell biologyImmunologyIn vitroEndocrinologyBiochemistryReceptorAdvanced Glycation End Products researchEndoplasmic Reticulum Stress and DiseaseConnexins and lens biology