Bacterial Transcription Factors Bind to Coding Regions and Regulate Internal Cryptic Promoters
Canfeng Hua, Jiadai Huang, Tingting Wang, Yue Sun, Jingui Liu, Linfeng Huang, Xin Deng
Abstract
Although bacterial TFs regulate transcription by binding to specific sequences at the promoter region, little is known about the mechanisms and functions of TFs binding within the CDS. In this study, we show that bacterial TFs have same binding pattern in both CDS and promoter regions, and we reveal three regulatory mechanisms of CDS-bound TF that together demonstrate the complexity of the regulatory mechanisms of bacterial TFs and the wide spread of internal cryptic promoters in CDS.
Topics & Concepts
PromoterTranscription factorTranscription (linguistics)Computational biologyCoding (social sciences)BiologyGeneticsCell biologyGeneGene expressionMathematicsStatisticsPhilosophyLinguisticsBacterial Genetics and BiotechnologyGenomics and Phylogenetic StudiesRNA and protein synthesis mechanisms