Augmented T-cell mitochondrial reactive oxygen species in adults with major depressive disorder
Ann‐Katrin Grotle, Ashley M. Darling, Erika F.H. Saunders, Paul J. Fadel, Daniel W. Trott, Jody L. Greaney
Abstract
To our knowledge, we provide the first evidence of augmented T-cell mitochondrial reactive oxygen species (T-cell mitoROS) in young, otherwise healthy adults with MDD. Although the elevated T-cell mitoROS did not correspond to a proinflammatory profile, these findings suggest that elevated T-cell mitoROS may be an early marker of immune system dysregulation in young adults with MDD.
Topics & Concepts
Reactive oxygen speciesMitochondrionBiologyCell biologyTryptophan and brain disordersStress Responses and CortisolIntensive Care Unit Cognitive Disorders