The mRNA Cap 2′- <i>O</i> -Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes
Graham D. Williams, Nandan S. Gokhale, Daltry L. Snider, Stacy M. Horner
Abstract
Induction of an efficient type I IFN response is important to control viral infection. We show that the host 2′- O -methyltransferase CMTR1 facilitates the protein expression of ISGs in human cells by preventing IFIT1 from inhibiting the translation of those mRNAs lacking cap 2′- O -methylation. Thus, CMTR1 promotes the IFN-mediated antiviral response.
Topics & Concepts
GeneMessenger RNAMethyltransferaseMolecular biologyInterferonGene expressionBiologyChemistryCell biologyGeneticsMethylationRNA modifications and cancerRNA Research and SplicingCancer-related gene regulation