Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides
Alessia Melacarne, Valentina Ferrari, Luca Tiraboschi, Michele Mishto, Juliane Liepe, Marina Aralla, Laura Marconato, Michela Lizier, Chiara Pozzi, Offer Zeira, Giuseppe Penna, María Rescigno
Abstract
T cells that recognize and kill human melanoma cells in vitro and when xenotransplanted in vivo. Hence, we identified a class of shared tumor antigens that are generated in ER-stressed cells, such as tumor cells, that do not induce tolerance and are not presented by healthy cells.
Topics & Concepts
Identification (biology)Class (philosophy)Fight-or-flight responseComputational biologyBiologyStress (linguistics)Unfolded protein responseImmunologyChemistryCell biologyGeneticsComputer scienceEndoplasmic reticulumGeneArtificial intelligenceEcologyLinguisticsPhilosophyImmunotherapy and Immune ResponsesImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers