Emodin 8-O-glucoside primes macrophages more strongly than emodin aglycone via activation of phagocytic activity and TLR-2/MAPK/NF-κB signalling pathway
Jisun Lee, Hyeon Jeong Kim, Trang Thi Huyen Nguyen, Seong‐Cheol Kim, Jin Ree, Tae Gyu Choi, Jae Kyung Sohng, Yong Il Park
Topics & Concepts
EmodinProinflammatory cytokineAglyconeNitric oxidep38 mitogen-activated protein kinasesChemistryNF-κBNitric oxide synthaseMAPK/ERK pathwayCytotoxicityBiochemistryDownregulation and upregulationSecretionPhagocytosisAnthraquinonesPharmacologySignal transductionBiologyCell biologyInflammationGlycosideImmunologyStereochemistryIn vitroOrganic chemistryGeneBotanyPhytochemistry and biological activity of medicinal plantsPharmacological Effects of Natural CompoundsBioactive Compounds and Antitumor Agents