Difluorination of heterobenzylic C–H bonds with <i>N</i>-fluoro-<i>N</i>-(fluorosulfonyl)carbamate (NFC)
Akiya Adachi, Takuya Hashimoto, Kohsuke Aikawa, Kyoko Nozaki, Takashi Okazoe
Abstract
Difluorination of heterobenzylic C–H bonds in N-heterocycles presented by pyridines was developed using a fluorinating reagent (NFC: N -fluoro- N -(fluorosulfonyl)carbamate) under mild reaction conditions.
Topics & Concepts
ChemistryCarbamateReagentMedicinal chemistryOrganic chemistryFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsCatalytic C–H Functionalization Methods