Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions
Samuel I. Bloom, Jordan R. Tucker, Jisok Lim, Tyler G. Thomas, Gregory J. Stoddard, Lisa A. Lesniewski, Anthony J. Donato
Topics & Concepts
TelomereSenescenceDNA damageVascular smooth muscleEndothelial dysfunctionBiologyCellular AgingThoracic aortaInternal medicineDNAAortaCell biologyEndocrinologyMedicineGeneticsSmooth muscleTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms