Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity
Weilin Chen, Xin Chen, Dongdong Li, Xianghan Wang, Guanlu Long, Zhengyu Jiang, Qidong You, Xiaoke Guo
Topics & Concepts
In vivoChemistryIn vitroMethyltransferaseDrug discoveryBiochemistryPharmacologyComputational biologyMethylationGeneticsBiologyDNAProtein Degradation and InhibitorsClick Chemistry and ApplicationsCancer-related gene regulation