Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells
Giacomo Canesin, Linda Feldbrügge, Guangyan Wei, Ľubica Janovičová, Monika Janíková, Eva Csizmadia, Juliana Ariffin, Andreas Hedblom, Zachary T. Herbert, Simon C. Robson, Peter Celec, Kenneth D. Swanson, Imad Nasser, Yury Popov, Barbara Wegiel
Abstract
drives M2-like Mϕ polarization. In summary, we identified LNX1/Notch1 pathway as a downstream target of HO-1 in liver fibrosis.
Topics & Concepts
HMOX1Heme oxygenaseFibrosisHepatic stellate cellHemeLiver injuryChemistryCirrhosisBile ductInflammationCancer researchBiologyCell biologyInternal medicineBiochemistryMedicineEndocrinologyImmunologyEnzymeHeme Oxygenase-1 and Carbon MonoxideOrgan Transplantation Techniques and OutcomesLiver Disease and Transplantation