Ib-AMP4 antimicrobial peptide as a treatment for skin and systematic infection of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA).
Samira Sadelaji, Ehsanollah Ghaznavi‐Rad, Shabnam Sadoogh Abbasian, Shohreh Fahimirad, Hamid Abtahi
Abstract
Objectives: situations. Materials and Methods: in a mouse model. Results: biomembrane. Time-kill curve and growth kinetic assay illustrated rapid antibacterial activity of the produced Ib-AMP4. Moreover, Ib-AMP4 showed significant infection treatment ability in a mouse model and all infected mice receiving Ib-AMP4 protein survived and there was no trace of bacteria in their blood samples. Conclusion: infection.
Topics & Concepts
Staphylococcus aureusMicrobiologyAntimicrobialMethicillin-resistant Staphylococcus aureusIn vivoRecombinant DNAEscherichia coliAntimicrobial peptidesAntibacterial activityIn vitroBacteriaBiologyPeptideChemistryBiochemistryGeneBiotechnologyGeneticsAntimicrobial Peptides and ActivitiesBiochemical and Structural CharacterizationProtein Hydrolysis and Bioactive Peptides