Steric Effects in the Deposition Mode and Drug-Delivering Efficiency of Nanocapsule-Based Multilayer Films
Li Xu, Zihan Chu, Jianhua Zhang, Tingwei Cai, Xingxing Zhang, Yinzhao Li, Hailong Wang, Xiaochen Shen, Raymond Cai, Haifeng Shi, Chunyin Zhu, Jia Pan, Donghui Pan
Abstract
-PDMAEMA)-by quaternization with methyl sulfate. As revealed by the data results, SNCs with coronas with higher quaternization degrees resulted in a larger layering distance of the film structure because of weaker ionic pairing (due to the presence of a bulky methyl spacer) between SNCs and PSS. Interestingly, when comparing the drug release profile of the encapsulated drugs from SNC-based films, the release rate was slower in the case of capsule coronas with higher quaternization degrees because of the larger diffusion distance of the encapsulated drugs and stronger hydrophobic-hydrophobic interactions between SNCs and drug molecules.