Electrospinning in Drug Delivery: Progress and Future Outlook
Nurfitrah Halim, Nithiskanna Nallusamy, Rajamani Lakshminarayanan, Seeram Ramakrishna, Sevakumaran Vigneswari
Abstract
There is intense research during the past few decades to design and fabricate drug delivery systems using the electrospinning system. Electrospinning is an efficient technique to produce nanofiber materials with different dimensions and morphologies by adjusting the processing parameters. Electrospinning is becoming an innovative technology that promotes the pursuit and maintenance of human health. Herein, the review discusses the contribution of electrospinning technology in drug delivery systems, summarising the modification of the various electrospinning system configurations and the effects of the process parameters on fibers, their application in drug delivery including carrier materials, loaded drugs and their release mechanisms and illustrates their various medical applications. Finally, this review discusses the challenges, bottlenecks, and development prospects of electrospinning technology in the field of drug delivery in terms of scaling up for clinical use and exploring potential solutions to pave the way to establish electrospinning for future drug delivery systems.